Scheme 4. Synthesis of Compounds 29 and 30.
Reagents and conditions: (a) Pd(OAc)2 (5 mol %), Xantphos (10 mol %), Cs2CO3, toluene, 130 °C. (b) 1 M NaOH, MeOH, rt. (c) 2-pyrrolidin-1-ylethanamine, TBTU, DIPEA, DMF, rt. (d) NBS, DCM, rt.
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