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RPA194 degradation measured in A375 cells. IC50 represents the mean of duplicate independent biological experiments performed in triplicate.
CYP1A2 inhibition analysis performed using human hepatic CYP450s (baculovirus–insect–cell expression system) expressing the isoform 1A2.
hERG inhibition analysis performed using HEK293 cells stably transfected with hERG cDNA and measured by QPatch. IC50 value represents the mean of n = 3.
