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. 2022 Mar 11;13(4):681–686. doi: 10.1021/acsmedchemlett.1c00715

Table 1. In Vitro PPARγ Profile of Compounds 1, 7, and 10.

compound 1 7 10
PPARγ binding IC50 (nM)a 90 ± 27 154 ± 12 24 ± 14
PPARγ GAL4 reporter gene EC50 (nM)/max agonist effectb (%)a 27 ± 16/86 ± 17 726c/28 ± 7 >50 000/27 ± 7
PPARγ pS273 IC50 (nM)a 4,400 ± 820 580 ± 44 160 ± 6
a

Values presented as the mean ± standard deviation (n ≥ 3).

b

Agonist effect at the highest assay concentration (50 μM).

c

Estimated EC50. (See the Supporting Information.)