Table 2. PK Parameters in Male Sprague Dawley Rats Following a 1.0 mg/kg Bolus Dose of 9.
| matrix | C0 (ng/mL) | Cavg (ng/mL) | CL (mL/min/kg) | Vd (L/kg) | T1/2 (h) | Fub |
|---|---|---|---|---|---|---|
| plasma | 628 | 52 | 40 | 1.8 | 0.8 | 0.03 |
| brain | 760 | 95 | 43 | 1.9 | 0.7 | 0.03 |
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