. 2022 Apr 1;13(4):701–706. doi: 10.1021/acsmedchemlett.2c00029

Table 1. ERK2 Inhibition Activity of Central Core Modification^a.

All IC₅₀ data are the mean of at least two independent measurements with variations of <15%; BVD-523 as positive control (EK2 IC₅₀ = 10.6 nM; Colo 205 IC₅₀ = 102.7 nM).

Enantiomer mixtures.

Table 1. ERK2 Inhibition Activity of Central Core Modificationa.

Table 1. ERK2 Inhibition Activity of Central Core Modification^a.