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. 2022 Mar 3;13(4):665–673. doi: 10.1021/acsmedchemlett.1c00682

Table 4. SAR of Truncated, Reversed Amides.

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a

Biochemical inhibition of PLD1/2 was determined by immunoprecipitation on a plate (IPoP) of PLD1/2 from HEK cells.

b

Cellular assay performed with Calu-1 cell line.

c

Rat or human liver microsomes.

d

Efflux ratio determined by measuring Papp(B-A)/Papp(A-B).

e

cassette dosing used; [Clu] = Unbound clearance (Cl/fu).