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. Author manuscript; available in PMC: 2022 Apr 18.
Published in final edited form as: Nature. 2020 Sep 23;586(7827):120–126. doi: 10.1038/s41586-020-2746-2

Extended Data Fig. 8 |. Chemical inhibition of autophagy synergizes with TNF treatment in a subset of human cancer cell lines.

Extended Data Fig. 8 |

Viability of MC38-OVA (a) and A375 (b) cells treated with antigen-specific T cells (OT-I at 5:1 and WT1 at 10:1 E:T ratios, respectively) and increasing concentrations of autophinib. n = 3 and 5 independent experiments. Error bars, s.e.m. (a, b). P values determined by two-way ANOVA with Fisher’s LSD comparison. c, Rank order of 91 cancer cell lines by their sensitivity synergy score to co-treatment with recombinant TNF (ranging from 0 to 100 U ml−1) and autophinib (ranging from 0 to 1,000 mM). Heat maps represent μ/μmax for all combinations in selected cell lines (MC38, A375 and NIH-2170) at 72 h after treatment. n = technical duplicates for each individual condition across all cell lines.