Table 2.
Spearman correlation coefficients between pre-diagnostic levels of inflammatory biomarkers and anthropometric factors among controls, adjusted for laboratory batch and age at blood donation
| Biomarkers | Adiponectin | Leptin | L to A ratio | CRP | TNF-α | IFN-γ | IL-6 | IL-8 | IL-10 | IL-1-RA | IL-17-D |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adiponectin | 1 | ||||||||||
| Leptin | − 0.18 | 1 | |||||||||
| L to A ratio | − 0.57 | 0.91 | 1 | ||||||||
| CRP | − 0.22 | 0.34 | 0.38 | 1 | |||||||
| TNF-α | − 0.05 | 0.08 | 0.09 | 0.16 | 1 | ||||||
| IFN-γ | − 0.02 | − 0.01 | 0.01 | 0.13 | 0.37 | 1 | |||||
| IL-6 | − 0.14 | 0.25 | 0.27 | 0.40 | 0.28 | 0.20 | 1 | ||||
| IL-8 | 0.03 | − 0.03 | − 0.04 | − 0.01 | 0.32 | 0.12 | 0.18 | 1 | |||
| IL-10 | − 0.01 | − 0.08 | − 0.06 | 0.01 | 0.33 | 0.27 | 0.09 | 0.16 | 1 | ||
| IL-1-RA | − 0.26 | 0.24 | 0.31 | 0.27 | 0.29 | 0.18 | 0.24 | 0.23 | 0.11 | 1 | |
| IL-17-D | 0.11 | − 0.05 | − 0.08 | − 0.07 | 0.07 | − 0.01 | 0.01 | 0.06 | 0.07 | − 0.02 | 1 |
| BMI | − 0.25 | 0.60 | 0.61 | 0.40 | 0.14 | 0.03 | 0.31 | 0.02 | − 0.03 | 0.34 | − 0.07 |
| Weight | − 0.23 | 0.55 | 0.55 | 0.35 | 0.12 | 0.02 | 0.27 | − 0.01 | − 0.02 | 0.31 | − 0.07 |
| Height | 0.03 | − 0.09 | − 0.09 | − 0.07 | − 0.02 | − 0.01 | − 0.06 | − 0.05 | 0.02 | − 0.03 | 0.01 |
| WC | − 0.29 | 0.53 | 0.57 | 0.35 | 0.15 | 0.05 | 0.28 | 0.01 | − 0.01 | 0.33 | − 0.06 |
| HC | − 0.15 | 0.56 | 0.54 | 0.33 | 0.09 | 0.03 | 0.24 | − 0.01 | − 0.01 | 0.27 | − 0.05 |
| WHR | − 0.27 | 0.24 | 0.32 | 0.20 | 0.14 | 0.05 | 0.19 | 0.03 | − 0.01 | 0.22 | − 0.04 |
Abbreviations: BMI, body mass index; CRP, c-reactive protein; HC, hip circumference; IFN, interferon; IL, interleukin; L to A, leptin to adiponectin; SD, standard deviation; RA: receptor antagonist; TNF, tumour necrosis factor; WC, waist circumference; WHR, waist-to-hip ratio
Spearman correlation coefficients with P values <0.0001 are in bold