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. 2022 Apr 18;23:30. doi: 10.1186/s12863-022-01041-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CYB5A WT transcript is decreased in CYB5Aalt-samples and shows an inverse correlation with CYB5Aalt mRNA expression. A CYB5A WT gene expression (TPM log2) in combined cohort 3 (n = 220) is shown across molecular subgroups. Circles resemble CYB5Aalt negative samples (n = 198), triangles resemble CYB5Aalt positive samples (n = 22). Subgroups with CYB5Aalt positive samples include NH/HeH (15/25), Ph-like (5/48), LH (1/12) and unknown (1/26). B Relation between CYB5A and CYB5Aalt gene expression (both in TPM log2) in CYB5Aalt positive samples (n = 22). Blue line represents linear regression line, grey area indicates 95% confidence interval