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. 2022 Apr 18;124:105799. doi: 10.1016/j.bioorg.2022.105799

Fig. 4.

Fig. 4

Time-dependent inhibition curve of hydroxamate 1a (1.25 µM) on Mpro (a). Progress curves of Mpro activity change in the presence of hydroxamate 1a and thiosemicarbazone 2b (b). 0.5% DMSO was used for the blank control.