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. 2022 Apr 18;124:105799. doi: 10.1016/j.bioorg.2022.105799

Table 1.

The inhibitory activities (IC50, μM) of hydroxamates and thiosemicarbazones on Mpro.

Compd. IC50 Compd. IC50 Compd. IC50 Compd. IC50
1a 0.12 1 g 18.78 2d 17.61 2j 3.25
1b 4.3 1 h 11.7 2e 8.45 2 k 28.81
1c 31.51 1i 3.6 2f 32.94 2 l 9.11
1d 0.15 2a 3.61 2 g 32.33 2 m 33.40
1e 0.42 2b 2.43 2 h 19.10 2n 20.74
1f 1.46 2c 4.37 2i 34.22