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. 2022 Apr 15;21:15347354221090221. doi: 10.1177/15347354221090221

Figure 1.

Figure 1.

(A–N) PS-T enhanced the anti-tumor effects (cell proliferation) of OXA and down-regulated P-gp level in human Bel-7404 and HepG2 hepatoma cells. (A and B) The viability of human hepatoma cells treated with PS-T was measured by CCK-8. (C and D) The viability of cells treated with PS-T, OXA, or PS-T plus OXA was estimated by CCK-8. (E–H) The estimation of cell proliferation was measured by EdU assay. (I) The representative images of clones indicated more powerful inhibition of cell proliferation explored to PS-T, OXA, or OXA plus PS-T. (J and K) Numbers of clones of human BEL-7404 and HepG2 cells were counted using Image J software and analyzed by Grahpad Prism 8.0. (L) PS-T down-regulated P-gp expression in human Bel-7404 and HepG2 cells. (M and N) Relative P-gp expression of cells, normalized to GAPDH, treated with PS-T in Bel-7404 and HepG2 cells. Data were shown as mean ± SD. Each experiment was repeated in triplicate. ##P < .05, **P < 0.05 represents statistically difference.