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. 2022 Mar 24;5(2):85–99. doi: 10.1093/abt/tbac008

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© The Author(s) 2022. Published by Oxford University Press on behalf of Antibody Therapeutics. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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CAR-T killing paradigm. (a–d) Bioimaging study of CAR-T killing. CAR-T cells were mixed with Nalm6 cells for phase contrast imaging under 20× objective on Nikon Biostation. Sequential images of CAR-T cells undergoing the processes of scanning, processing, killing and release was composed as a montage by ImageJ. A cross indicated target cell; arrows indicated filopodia. (e) Working hypothesis of CAR-T killing. Active CAR-T cells scan for prey randomly, followed by processing, killing, capturing of a new prey and releasing the victim.