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. 2021 Nov 17;145(2):621–631. doi: 10.1093/brain/awab322

Figure 3.

Figure 3

Clinical profiles of ALS clusters derived from EEG measures are concordant with the neurophysiological profiles. The four EEG clusters (colour-coded) suggest different trends in functional/clinical scores in different domains: (A) normalized ALSFRS-R (bulbar, limb and respiratory) and (B) z-scored ECAS (language, fluency, executive, memory and visuospatial) and normalized BBI (behaviour) score are all non-significant (P > 0.05, FDR). (C) Kaplan–Meier survival curves corresponding to the ALS clusters. (D–F) Clinical characteristics. Clinical subscores (A and B) are all normalized or standardized, see the ‘Materials and methods’ section. Note that there are in total: five ALS-FTD, 11 C9orf72-positive and four respiratory-onset patients. Statistical tests: Kruskal–Wallis one-way ANOVA (A and B), logrank test (C) and Fisher’s exact test (D–F); all FDR corrected.