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. 2021 Sep 17;145(2):684–699. doi: 10.1093/brain/awab300

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Interactome of all five DPRs using BioID2 pull-down. (A) Schematic representation of constructs and pull-down experiments. The five DPR constructs consisted of 125 DPRs. (B) Venn diagram illustrating the overlap between the total interactors of the five DPRs after proteomic analysis, for Quant ratio versus control >2.0. The Venn diagram was prepared using the online tool provided by VIB and Ghent University (http://bioinformatics.psb.ugent.be/webtools/Venn/). (C) GO enrichment analysis for the interactors with Quant ratio versus BioID >2.0, showing the involvement of DPR interactors in different biological processes. There was no enrichment in the biological processes for polyGP interactors. P-values were derived via the DAVID algorithm.