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. 2021 Sep 17;145(2):684–699. doi: 10.1093/brain/awab300

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Cellular localization of DPRs and VCP in HEK293 cells. (A) HEK293 cells transfected with the DPR constructs, revealed using an anti-Myc antibody (green) and endogenous VCP (red). VCP co-localized with polyGA, but not with the other DPRs. The line profile plot indicates the intensity distribution of the green and red channels through the white line in the magnified view of the region of interest (ROI) in the merged panel (middle). Scale bars = 20 µm. (B) Representative proximity ligation assay (PLA) using anti-Myc and anti-VCP antibodies revealed interactions between polyGA and VCP (red dots).