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. 2022 Apr 14;219(6):e20212553. doi: 10.1084/jem.20212553

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© 2022 Castleman et al.

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Figure 4. — SARS-CoV-2 infection is associated with increased BCR signaling ability by B_ND cells. (A) Representative histogram expression (geometric mean fluorescent intensity) of pSYK Y348, pBLNK Y84, or pPLCγ2 Y759 in B_ND cells with (+) or without (−) 10 μg/ml anti-IgG (H + L) F(ab’)2 treatment for 5 min from healthy controls (white histograms), those immunized against SARS-CoV-2 (grey histograms), mild (pink histograms), or severe SARS-CoV-2 (red histograms). The control histogram (dashed line) is a B_ND FMO from healthy controls. (B) Summary quantification of phosphorylated protein expression in each patient population of healthy controls (n = 10), those immunized against SARS-CoV-2 (n = 14), mild (n = 8) or severe (n = 12) SARS-CoV-2 infection (+) or without (−) treatment. Statistics: one-way ANOVA; *, P < 0.05; **, P > 0.01.