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. 2022 Apr 14;219(6):e20212553. doi: 10.1084/jem.20212553

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© 2022 Castleman et al.

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Figure 5. — B_ND cells from individuals with severe SARS-CoV-2 infection have a BCR signaling capacity similar to Naive B cells. (A) Expression (geometric mean fluorescent intensity) of pSYK Y348, pBLNK Y84, or pPLCγ2 Y759 in B_ND cells (light blue) as compared with transitional T2 (royal blue), and Naive B cells (medium blue) from severe SARS-CoV-2 infection (n = 12) after 10 μg/ml anti-IgG (H + L) F(ab’)2 treatment for 5 min shown as representative histogram. The control histogram (dashed line) is a B_ND FMO from healthy controls. (B) Quantification of pSYK, pBLNK, and pPLCγ2 after BCR stimulation in T2, Naive, or B_ND cells. (C) Pairwise matching of Naive and B_ND cells from severe SARS-CoV-2 infection (n = 12). Statistics: one-way ANOVA or paired t test; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.