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. 2022 Apr 14;219(6):e20212553. doi: 10.1084/jem.20212553

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© 2022 Castleman et al.

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Figure 6. — SARS-CoV-2 infected individuals have higher titers of autoreactive antibodies than immunized controls. (A) Total levels of IgM or IgG were quantified in plasma from subjects immunized against SARS-CoV-2 (n = 10) or those mildly (n = 12) or severely infected with SARS-CoV-2 (n = 14). (B and C) Titers of autoreactive antibodies with specificity to autoantigens chromatin, cardiolipin, and Smith antigen were measured in plasma from subjects immunized against SARS-CoV-2 (n = 10), or those mildly (n = 12) or severely infected with SARS-CoV-2 (n = 14), then normalized to total IgM (B) or total IgG (C). (D) Titers of VH4-34 antibodies were measure in plasma then normalized to total IgG. Statistics: One-way ANOVA; *, P < 0.05; **, P < 0.01; ***, P < 0.001.