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. 2022 Apr 14;219(6):e20212553. doi: 10.1084/jem.20212553

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© 2022 Castleman et al.

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Figure 7. — CRP levels during severe SARS-CoV-2 infection correlate with altered B_ND phenotype and function. (A) Quantification of CRP (µg/ml) in plasma from those immunized (n = 8) against SARS-CoV-2, mild (n = 10), or severe SARS-CoV-2 infection (n = 13). (B and C) Correlation of levels of CRP (µg/ml) in plasma with phenotypic markers on B_ND cells (geometric mean fluorescent intensity; B) or with (C) expression of pSYK Y348, pBLNK Y84, or pPLCγ2 Y759 in B_ND cells with 10 μg/ml anti-IgG (H + L) F(ab’)2 treatment for 5 min from those immunized against SARS-CoV-2 (n = 8), mild (n = 8), or severe SARS-CoV-2 infection (n = 10). Statistics: one-way ANOVA or Pearson correlation; ****, P < 0.0001.