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. 2022 Apr 14;219(6):e20212553. doi: 10.1084/jem.20212553

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© 2022 Castleman et al.

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Figure S3. — BCR signaling is specific to CD19⁺ B cells and phosphorylation proximal to the BCR occurs rapidly. (A) Expression (geometric mean fluorescent intensity) of pSYK Y348, pBLNK Y84, and pPLCγ2 Y759 in CD3⁺ T cells or CD19⁺ B cells from healthy controls (n = 6) after 5-min incubation with (+) or without (−) anti-IgG (H + L) F(ab’)2. (B) Expression of pSYK Y348, pBLNK Y84, and pPLCγ2 Y759 in CD19⁺ B cells from healthy controls (n = 1, repeated three times) after 2- or 5-min incubation with anti-IgG (H + L) F(ab’)2. Statistics: one-way ANOVA; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.