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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: DNA Repair (Amst). 2021 May 11;105:103134. doi: 10.1016/j.dnarep.2021.103134

Fig. 3.

Fig. 3.

Simplified scheme illustrating formaldehyde reactions involved in canonical one-carbon metabolism. Distinct cytoplasmic and mitochondrial one-carbon metabolism reactions enable eukaryotic cells to support biochemical processes, such as nucleotide, amino acid and methyl group biosynthesis, essential for survival and DNA metabolism. The figure was adapted from reference 28.