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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: DNA Repair (Amst). 2021 May 11;105:103134. doi: 10.1016/j.dnarep.2021.103134

Fig. 6.

Fig. 6.

Inflammatory signalling pathways activated by mtDNA. In mammalian cells, the release of mtDNA into the cytosol induces different inflammatory signalling pathways, including endosomal localized TLR9, cGAS-STING or the cytosolic inflammasome (AIM2 or NLRP3).