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Representative diagram of the interaction between anorectic hormones, molecular pathways, and neuropeptides POMC and AgRP. Anorexigenic hormones (leptin and insulin) act on the hypothalamic arcuate nucleus, reducing AMPK activation in AgRP neurons, thus reducing its expression. In POMC neurons, hormones increase mTOR activity and reduce AMPK, increasing its expression and reducing food intake and eutrophic phenotype.
