TABLE 1.
Classification of quinolones in the training group by use of the discriminant function obtained by LDAa
| Quinolone | M | Predicted activity | Quinolone | M | Predicted activity | |
|---|---|---|---|---|---|---|
| Active | Inactive | |||||
| AMQ1 | 5.00 | + | PD107572 | −3.55 | − | |
| AMQ2 | 4.05 | + | PD108666 | −9.39 | − | |
| AMQ3 | 4.13 | + | PD108685 | −6.14 | − | |
| AMQ4 | 2.90 | + | PD108758 | −6.58 | − | |
| AMQ5 | 4.88 | + | PD108970 | −7.70 | − | |
| AMQ6 | 4.56 | + | PD109073 | −0.08 | − | |
| PD115311 | −2.45 | − | PD109205 | −6.53 | − | |
| PD117579 | 1.43 | + | PD109631 | 1.18 | + | |
| PD117596 | 1.78 | + | PD109813 | −2.02 | − | |
| PD118013 | 2.08 | + | PD110869 | −3.53 | − | |
| PD119421 | 4.03 | + | PD110920 | −6.13 | − | |
| PD119805 | 3.06 | + | PD111518 | −2.46 | − | |
| PD119977 | 4.48 | + | PD111700 | −5.46 | − | |
| PD120114 | 2.39 | + | PD111754 | −1.39 | − | |
| PD120316 | 3.81 | + | PD111834 | −6.46 | − | |
| PD120683 | 4.24 | + | PD112388 | −3.56 | − | |
| PD121285 | 1.74 | + | PD113721 | −7.14 | − | |
| PD122642 | 0.37 | + | PD114033 | −6.43 | − | |
| PD123982 | 2.91 | + | PD114111 | −1.06 | − | |
| PD125354 | 4.26 | + | PD114507 | −5.32 | − | |
| PD125554 | 7.04 | + | PD114843 | −5.54 | − | |
| PD125999 | 5.35 | + | PD114950 | −7.04 | − | |
| PD126889 | 4.77 | + | PD114980 | −4.86 | − | |
| PD131413 | 1.48 | + | PD115896 | −2.43 | − | |
| PD135042 | 5.49 | + | PD116427 | −5.28 | − | |
| PD135144 | 4.08 | + | PD117186 | −5.69 | − | |
| PD135739 | −0.95 | − | PD118362 | −5.38 | − | |
| PD137156 | 3.59 | + | PD119035 | −4.90 | − | |
| PD137954 | −0.59 | − | PD119244 | −6.90 | − | |
| PD138032 | 4.68 | + | PD119344 | −0.23 | − | |
| PD138926 | 3.39 | + | PD120261 | −1.03 | − | |
| PD139586 | 1.77 | + | PD120262 | −7.13 | − | |
| PD142421 | 8.27 | + | PD120818 | −1.13 | − | |
| PD143170 | 1.55 | + | PD120896 | −7.68 | − | |
| PD144881 | 2.61 | + | PD120978 | −4.46 | − | |
| PD158804 | 3.54 | + | PD121054 | −4.25 | − | |
| PD160788 | 5.85 | + | PD121264 | −4.37 | − | |
| PD160790 | 3.17 | + | PD123972 | 0.78 | + | |
| PD160792 | 3.94 | + | PD125639 | 1.82 | + | |
| PD160793 | 4.57 | + | PD127275 | 1.91 | + | |
| PD160826 | 2.23 | + | PD127367 | 0.90 | + | |
| PD161144 | 5.70 | + | PD130426 | −2.04 | − | |
| PD161314 | 5.18 | + | PD131161 | −2.87 | − | |
| PD161315 | 4.03 | + | PD131199 | −2.91 | − | |
| PD161316 | 6.34 | + | PD135723 | 0.40 | + | |
| PD161649 | 5.64 | + | PD135964 | −5.86 | − | |
| PD161650 | −0.86 | − | PD138362 | −0.75 | − | |
| PD161654 | −0.58 | − | PD139735 | −3.13 | − | |
| PD162279 | 3.03 | + | PD160336 | −0.53 | − | |
| PD162280 | 3.97 | + | PD161147 | −4.18 | − | |
| PD162281 | 4.73 | + | PD161318 | −1.12 | − | |
| PD162282 | 5.22 | + | PD161323 | −2.18 | − | |
| PD163051 | 3.02 | + | PD161546 | −5.00 | − | |
| PD163052 | 3.81 | + | PD162277 | −2.01 | − | |
| PD163054 | 5.16 | + | PD163451 | 0.11 | + | |
| PD163450 | 1.96 | + | PD163655 | −0.08 | − | |
| PD163755 | −2.39 | − | T3761 | 1.06 | + |