TABLE 3.

Comparison of predictions of activity by molecular topology and LDA analysis versus experimental MICs

Quinolone	LDA analysis result		Experimental MIC (μg/ml)
	M value	Predicted activity
Moxifloxacin	3.90	Active	0.2
Sparfloxacin	5.06	Active	0.4
Gatifloxacin	4.54	Active	0.9
Temafloxacin	−0.21	N.C.a	1.0
Levofloxacin	0.77	N.C.	2.1
Ofloxacin	0.77	N.C.	2.5
Trovafloxacin	1.69	Active	2.7
Ciprofloxacin	7.20	Active	2.8
Lomefloxacin	−1.28	Inactive	4.5
Clinafloxacin	2.16	Active	5.0
Grepafloxacin	3.85	Active	5.4
Fleroxacin	−0.18	N.C.	8.1
Pefloxacin	1.13	N.C.	10.0
Norfloxacin	−0.95	N.C.	11.4
Enoxacin	−1.78	Inactive	13.7
Acrosoxacin	−0.68	N.C.	23.5
Rufloxacin	0.51	N.C.	31.0
Irloxacin	−3.63	Inactive	47.2
Pipemidic acid	−1.97	Inactive	>250.0
Flumequine	−1.96	Inactive	>250.0
Piromidic acid	−4.43	Inactive	>250.0
Nalidixic acid	−3.65	Inactive	>250.0
Cinoxacin	−2.24	Inactive	>250.0
Oxolinic acid	−3.25	Inactive	>250.0

^aN.C., not classified.