FIGURE 1.

Validation of the model establishment for cerebral ischemic rats. (a) Body weight changes in rats after middle cerebral artery occlusion (MCAO). (b) Locomotion in cerebral ischemic rats examined by a rotarod test. (c) Neurological damage in rats with cerebral ischemia assessed by neurological deficit score. (d) Brain water content assessment of cerebral edema in rats with cerebral ischemia. (e) Infarct volume in rats with cerebral ischemia detected by 2,3,5‐triphenyl tetrazolium chloride (TTC) staining. Data are expressed as mean ± SD, and statistical significance was determined using unpaired t‐test (b–e) or two‐way analysis of variance (ANOVA) (a), followed by Tukey multiple comparison test. *p < .05