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. 2022 Mar 8;12(4):e2522. doi: 10.1002/brb3.2522

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© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Activating transcription factor 3 (ATF3)/CCL2 regulates ischemic injury in rat brain. (a) Body weight changes in rats after middle cerebral artery occlusion (MCAO). (b) Locomotion in cerebral ischemic rats examined by a rotarod test. (c) Neurological damage in rats with cerebral ischemia assessed by neurological deficit score. (d) Brain water content assessment of cerebral edema in rats with cerebral ischemia. (e) Infarct volume in rats with cerebral ischemia detected by 2,3,5‐triphenyl tetrazolium chloride (TTC) staining. Data are expressed as mean ± SD, and statistical significance was determined using one‐way analysis of variance (ANOVA) (b–e) or two‐way ANOVA (a), followed by Tukey multiple comparison test. *#p < .05