TABLE 3.
SMD (95% CI) | p | |||||
---|---|---|---|---|---|---|
Trim and fill analysis | Trials (n) | Before adjusted | After adjusted | Before adjusted | After adjusted | Adjusted studies |
BDNF, ng/ml (Long‐term effect) | 17 | 0.68 (0.27, 1.08) | Unchanged | .001 | Unchanged | – |
Sample size > 20 | 11 | 0.93 (0.34, 1.52) | Unchanged | .002 | Unchanged | – |
Age ≥ 60 years | 11 | 0.95 (0.35, 1.55) | 0.80 (0.17, 1.44) | .002 | .014 | 3 |
BMI ≥ 25 | 8 | 0.65 (0.07, 1.24) | Unchanged | .029 | Unchanged | – |
Aerobic exercise | 15 | 0.86 (0.37, 1.36) | Unchanged | .001 | Unchanged | – |
SMD (95% CI) | P | |||||
---|---|---|---|---|---|---|
Leave‐one‐out cross validation | Trials (n) | Before adjusted | After adjusted | Before adjusted | After adjusted | Omitted studies |
BDNF, ng/ml (Acute effect) | 5 | 1.20 (0.36, 2.04) | 0.60 (0.32, 0.88) | .005 | <.001 | 1 |
BDNF, ng/ml (Long‐term effect) | 17 | 0.68 (0.27, 1.08) | 0.38 (0.13, 0.62) | .001 | .003 | 7 |
Note: Significant p‐values are highlighted in bold prints.
Abbreviations: BDNF, brain‐derived neurotrophic factor; BMI, body mass index; CI, confidence interval.