Fig 2. Regional association plot for the region around rs4253311 on chromosome 4: (A) GCKD study (discovery) and (B) YFS cohort (replication).

Plots are produced in LocusZoom and show the most strongly associated SNP (purple diamond), SNP colors reflect LD correlation (r²) using 1000G EUR population as reference. The -log₁₀ p-values (left y-axis) of SNPs are shown according to their chromosomal positions (x-axis, GRCh37); the genetic recombination rates are shown on the right y-axis. The -log₁₀ p-values are shown for both genotyped and imputed SNPs distributed in a 0.8-megabase genomic region.