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. 2022 Apr 18;17(4):e0267140. doi: 10.1371/journal.pone.0267140

Fig 2. Study overview.

Fig 2

A cohort of 242 patients were included in the internal evaluation phase according to the date of recruitment to the TAILORED-Treatment study. This cohort was used to compare the prediction performances of the classifiers using eCRF variables alone, as well as classifiers using both eCRF and microbiota variables (Internal evaluation phase). In the expanded cohort (51 extra patients), 5-fold cross-validation (CV) analysis was conducted to evaluate the contribution of eCRF and microbiota variables to prediction performance (Cross-validation phase). CC: Classifier using CRP only in the initial cohort. CE: Classifiers using two or more eCRF variables (incl. CRP) in the initial cohort. CEM: Classifiers using all input eCRF variables (incl. CRP) and at least one microbiota in the initial cohort. CC*: Classifier using CRP only in the 5-fold CV of the expanded cohort. CEM*: Classifiers using two or more variables (regardless eCRF or microbiota) in the 5-fold CV of the expanded cohort. CCM*: Classifiers using CRP and all input microbiota variables in the 5-fold CV of the expanded cohort. AUC: Area Under the ROC Curve.