FIG. 2.

Treatment of MAC-infected MM6 cells with compound 78 (SRI-20094). MM6 cells were infected with MAC strain NJ3404 as described in Materials and Methods. CFUs were determined in triplicate at 0 and 7 days for nontreated (○) cells and those treated with 0.5 μg (●) of compound 78 per ml and 1.5 μg (▪) of compound 78 per ml. Values represent the mean plus or minus standard error of the mean for triplicate assays. The differences between the mean values for the cells treated with 0.5 μg and 1.5 μg of compound 78 per ml versus the nontreated control cells were both significant at a P value of <0.001. Significance was determined by one-way analysis of variance, and a correction for multiple comparisons (posttest) was performed by the Tukey-Kramer multiple-comparisons test using InStat (GraphPad Software).