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. 2022 Feb 8;94(5):1846–1865. doi: 10.1002/jmv.27615

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© 2022 Wiley Periodicals LLC

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

PMC Copyright notice

Diversity of type I IFN production and life‐threatening COVID‐19 pneumonia. It has been demonstrated that variants at the TLR3‐ and IRF7‐dependent type I IFN immunity are related to life‐threatening COVID‐19 pneumonia and asymptomatic infection. ⁸⁷ COVID‐19, coronavirus disease 2019; IRF7, interferon regulatory factor 7; IFN, interferon; TLR3, toll‐like receptor 3 (TLR3)