Figure 3.

IgG subtypes and Th2 oriented cytokines elicited by different immunization schedules for inactivated severe acute respiratory syndrome coronavirus 2 vaccines. (A) S‐specific IgG1. (B) S‐specific IgG2a. (C) IgG1/IgG2a ratio. (D) and (E) IL‐4 and IL‐13 secreted by splenocytes upon stimulation with the S protein. N = 6, points represent individual mice. Data were compared using one‐way analysis of variance followed by Dunnett's multiple comparisons tests, with Group c as the control. *p < 0.05; **p < 0.01; ***p < 0.001. PBS, phosphate‐buffered saline