TABLE 1.
Correlation analysis between RIMKLB and related gene markers of immune cells in COAD and READ.
| Cell Type | Marker | COAD | READ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| None | Purity | None | Purity | ||||||
| Cor* | p Value | Cor | p Value | Cor* | p Value | Cor | p Value | ||
| CD8+ T cell | CD8A | 0.203 | 1.22E-05 | 0.129 | 9.43E-03 | 0.342 | 7.64E-06 | 0.237 | 5.00E-03 |
| CD8B | 0.178 | 1.34E-04 | 0.157 | 1.51E-03 | 0.204 | 8.49E-03 | 0.112 | 1.90E-01 | |
| T cell (general) | CD3D | 0.202 | 1.34E-05 | 0.131 | 8.16E-03 | 0.191 | 1.39E-02 | 0.048 | 5.71E-01 |
| CD3E | 0.28 | 1.29E-09 | 0.218 | 9.24E-06 | 0.285 | 2.10E-04 | 0.159 | 6.18E-02 | |
| CD2 | 0.259 | 2.12E-08 | 0.185 | 1.73E-04 | 0.321 | 2.85E-05 | 0.206 | 1.51E-02 | |
| B cell | CD19 | 0.233 | 4.42E-07 | 0.15 | 2.43E-03 | 0.087 | 2.632–01 | 0.01 | 9.11E-01 |
| CD79A | 0.278 | 1.62E-09 | 0.186 | 1.59E-04 | 0.194 | 1.22E-02 | 0.054 | 5.28E-01 | |
| Monocyte | CD86 | 0.404 | 0.00E + 00 | 0.357 | 1.11E-13 | 0.478 | 9.65E-11 | 0.395 | 1.52E-06 |
| CD115 | 0.491 | 0.00E + 00 | 0.474 | 4.09E-24 | 0.423 | 1.95E-08 | 0.332 | 6.68E-05 | |
| TAM | CCL2 | 0.463 | 0.00E + 00 | 0.422 | 5.31E-19 | 0.515 | 0.00E + 00 | 0.438 | 6.71E-08 |
| CD68 | 0.32 | 2.16E-12 | 0.289 | 3.15E-09 | 0.357 | 2.80E-06 | 0.277 | 9.52E-04 | |
| IL10 | 0.324 | 1.20E-12 | 0.29 | 2.47E-09 | 0.233 | 2.57E-03 | 0.151 | 7.60E-02 | |
| M1 macrophage | INOS | −0.194 | 3.09E-05 | −0.23 | 2.26E-06 | −0.085 | 2.78E-01 | −0.044 | 6.05E-01 |
| IRF5 | 0.336 | 1.92E-13 | 0.354 | 1.91E-13 | 0.237 | 2.16E-03 | 0.203 | 1.66E-02 | |
| COX2 | 0.187 | 5.59E-05 | 0.12 | 1.54E-02 | 0.256 | 9.20E-04 | 0.159 | 6.11E-02 | |
| M2 macrophage | CD163 | 0.474 | 0.00E + 00 | 0.451 | 9.60E-22 | 0.529 | 0.00E + 00 | 0.452 | 2.34E-08 |
| VSIG4 | 0.443 | 0.00E + 00 | 0.414 | 2.75E-18 | 0.314 | 4.20E-05 | 0.22 | 9.12E-03 | |
| MS4A4A | 0.403 | 0.00E + 00 | 0.365 | 3.06E-14 | 0.455 | 1.11E + 09 | 0.093 | 4.33E-01 | |
| Neutrophils | CD66b | −0.111 | 1.73E-02 | −0.12 | 1.67E-02 | −0.379 | 4.84E-07 | −0.3 | 3.47E-04 |
| CD11b | 0.468 | 0.00E + 00 | 0.445 | 3.50E-21 | 0.526 | 0.00E + 00 | 0.434 | 9.43E-08 | |
| CCR7 | 0.338 | 1.34E-13 | 0.271 | 2.78E-08 | 0.187 | 1.61E-02 | 0.121 | 1.56E-01 | |
| Natural killer cell | KIR2DL1 | 0.08 | 8.72E-02 | 0.034 | 4.95E-01 | 0.186 | 1.66E-02 | 0.166 | 5.02E-02 |
| KIR2DL3 | 0.085 | 6.85E-02 | 0.075 | 1.31E-01 | 0.182 | 1.88E-02 | 0.174 | 4.07E-02 | |
| KIR2DL4 | −0.023 | 6.23E-01 | −0.1 | 4.33E-02 | 0.1 | 2.01E-01 | −0.032 | 7.12E-01 | |
| KIR3DL1 | 0.104 | 2.60E-02 | 0.051 | 3.04E-01 | 0.08 | 3.08E-01 | 0.041 | 6.34E-01 | |
| KIR3DL2 | 0.136 | 3.63E-03 | 0.076 | 1.28E-01 | 0.199 | 1.01E-02 | 0.114 | 1.83E-01 | |
| KIR3DL3 | −0.061 | 1.89E-01 | −0.06 | 2.38E-01 | −0.051 | 5.11E-01 | −0.099 | 2.48E-01 | |
| KIR2DS4 | 0.033 | 4.86E-01 | 0.016 | 7.47E-01 | 0.065 | 4.07E-01 | −0.027 | 7.48E-01 | |
| Dendritic cell | HLA-DPB1 | 0.37 | 2.33E-16 | 0.317 | 6.40E-11 | 0.331 | 1.52E-05 | 0.211 | 1.27E-02 |
| HLA-DQB1 | 0.218 | 2.61E-06 | 0.158 | 1.40E-03 | 0.097 | 2.12E-01 | 0.041 | 6.35E-01 | |
| HLA-DRA | 0.271 | 4.33E-09 | 0.21 | 1.96E-05 | 0.325 | 2.11E-05 | 0.211 | 1.25E-02 | |
| HLA-DPA1 | 0.32 | 2.29E-12 | 0.263 | 7.80E-08 | 0.355 | 3.07–06 | 0.228 | 6.97E-03 | |
| BDCA-1 | 0.339 | 9.49E-14 | 0.296 | 1.17E-09 | 0.195 | 1.16E-02 | 0.069 | 4.17E-01 | |
| BDCA-4 | 0.546 | 0.00E + 00 | 0.514 | 1.05E-28 | 0.672 | 0.00E + 00 | 0.619 | 4.48E-16 | |
| CD11c | 0.484 | 0.00E + 00 | 0.454 | 4.51E-22 | 0.496 | 5.97E-12 | 0.432 | 1.12E-07 | |
| Th1 | T-bet | 0.267 | 6.68E-09 | 0.226 | 4.43E-06 | 0.367 | 1.18E-06 | 0.281 | 8.06E-04 |
| STAT4 | 0.308 | 2.00E-11 | 0.267 | 4.70E-08 | 0.332 | 1.37E-05 | 0.272 | 1.21E-03 | |
| STAT1 | 0.258 | 2.02E-08 | 0.224 | 5.36E-06 | 0.445 | 2.84E-09 | 0.363 | 1.12E-05 | |
| IFN-γ | 0.077 | 9.99E-02 | 0.041 | 4.11E-01 | 0.301 | 7.96E-05 | 0.209 | 1.34E-02 | |
| TNF-α | 0.21 | 5.90E-06 | 0.17 | 5.77E-04 | 0.226 | 3.41E-03 | 0.131 | 1.23E-01 | |
| Th2 | GATA3 | 0.486 | 1.52E-28 | 0.439 | 1.61E-20 | 0.422 | 1.99E-08 | 0.337 | 4.90E-05 |
| STAT6 | 0.247 | 8.08E-08 | 0.253 | 2.36E-07 | 0.181 | 2.01E-02 | 0.206 | 1.49E-02 | |
| STAT5A | 0.271 | 4.36E-09 | 0.273 | 2.17E-08 | 0.137 | 7.94E-02 | 0.122 | 1.53E-01 | |
| IL13 | 0.161 | 5.62E-04 | 0.104 | 3.59E-02 | 0.127 | 1.02E-01 | −0.008 | 9.22E-01 | |
| Tfh | BCL6 | 0.459 | 0.00E + 00 | 0.425 | 3.27E-19 | 0.597 | 0.00E + 00 | 0.595 | 1.18E-14 |
| IL21 | 0.102 | 2.85E-02 | 0.066 | 1.81E-01 | 0.061 | 4.43E-01 | 0.036 | 6.73E-01 | |
| Th17 | STAT3 | 0.246 | 1.02E-07 | −0.27 | 5.16E-08 | 0.403 | 9.86E-08 | 0.339 | 3.47E-04 |
| IL17A | −0.157 | 7.46E-04 | −0.16 | 1.35E-03 | −0.21 | 6.60E-03 | −0.186 | 2.82E-02 | |
Cor*: Correlation.