Table 3.

Sense mutations in spike protein gene in SARS‐CoV‐2 variants of concern ⁷⁷ , ⁷⁸ , ⁷⁹

Lineage	Earliest documented samples	The most important sense mutations in spike protein gene
B.1.1.7	September 2020	N501Y, D614G, P681H
(Alpha)	UK
B.1.351	May 2020	K417N, E484K, N501Y, D614G, A701V
(Beta)	South Africa
P.1	November 2020	K417T, E484K, N501Y, D614G, H655Y
(Gamma)	Brazil
B.1.617.2	October 2020	L452R, T478K, D614G, P681R
(Delta)	India

Abbreviation: SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.