Figure 3.
Representative dose‐response curves of selected PLpro inhibitors. Representative dose‐response curves used to determine IC50‐values for the PLpro inhibitors (a) GRL0617 (black triangles), PLpro inhibitor 6 (red boxes), auranofin (blue circles), and (b) PBIT (lavender boxes), ebselen (orange triangles), disulfiram (green circles). Two dose‐response curves each composed of technical duplicates were independently determined using SPE‐MS PLpro inhibition assays, performed as described in the Supporting Information (Section 5).
