Table 1.

Amino acid substitutions present in SARS‐CoV‐2 Spike (receptor‐binding domain) Omicron variant

Substitutions	Span of time from the first date of publication (in months)	Publication month, year	References
S373P	0	Oct, 2020	Long et al. ³
G496S^a	5	Mar, 2021	Teng et al. ⁴
G339D	6	Apr, 2021	Smaoui and Yahyaoui ⁵
S375F	6	Apr, 2021	Chen et al. ⁶
G446S,^a T478K,^a Q493K,^a and Y505H^a	8	Jun, 2021	Verma and Subbarao ⁷
K417N	8	Jun, 2021	Barton et al. ⁸
N440K,^a S477N,^a and N501Y ^a	9	July, 2021	Gan et al. ⁹
Q498R^a	10	Aug, 2021	Zahradník et al. ¹⁰
E484A^a	12	Oct, 2021	Laurini et al. ¹¹

^{^a}

Receptor‐binding motif; In bold: shared substitutions in SARS‐CoV‐2 VOI and/or VOC.