. Author manuscript; available in PMC: 2022 Apr 18.

Published in final edited form as: Clin Lab Med. 2020 Dec 23;41(1):15–34. doi: 10.1016/j.cll.2020.10.002

Table 2.

RCTs comparing liberal versus restricted platelet transfusion in ELBW infants

Trial	Patient Population	Platelet Thresholds	Primary Outcome	Results
Andrew, et al.⁸⁸	152 infants; GA <33 weeks; BW 500–1500g; platelet count <150,000/μL during the first 72 hours of life	150,000/μL vs 50,000/μL	Incidence or extension of ICH	No difference in new/worsening ICH between higher and lower threshold (28% vs 26%, P=0.73); higher threshold received less FFP and RBCs
Curley, et al. PlaNeT-2 Trial⁸⁹	660 infants; GA <34 weeks; Platelet count <50,000/μL	50,000/μL vs 25,000/μL	Death or new major bleeding	Higher rates of death or major bleeding in higher threshold group; OR, 1.57; 95% CI, 1.06 to 2.32; P=0.02
Kumar, et al.⁹²	44 infants; GA <35 weeks; PDA detected at <14 days of age; platelet count <100,000/μL	100,000/μL vs 20,000/ μL	Mean time to PDA closure	No significant difference in time to PDA closure; Adjusted HR 1.4 (95% CI 0.57–3.47), P=0.46

Abbreviations: RCT, randomized controlled trial; GA, gestational age; BW, birth weight; ICH, intracranial hemorrhage; OR, odds ratio; CI, confidence interval; PDA, patent ductus arteriosus; HR, hazard ratio