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. 2022 Apr 4;10:838785. doi: 10.3389/fcell.2022.838785

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Copyright © 2022 Chu, Wang, Zhang, Liu, Sun, Liang, Zhang, An, Wei, Zhu, Guo, Zhao, Fu, Xu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expressions of caspase-1, GSDMD, IL-1β, and IL-18 are up-regulated in DVT patients. (A) mRNA level of caspase-1 in the PBMCs from 30 DVT patients and 30 controls was determined by qRT-PCR. (B) Caspase-1 and GSDMD protein levels were measured in PBMCs of DVT subjects and controls by Western blot. (C,D) Protein levels of IL-1β and IL-18 in the serum from 12 DVT patients and 12 controls were determined by ELISA. ****p < 0.0001.