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. 2022 Apr 4;10:838785. doi: 10.3389/fcell.2022.838785

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Copyright © 2022 Chu, Wang, Zhang, Liu, Sun, Liang, Zhang, An, Wei, Zhu, Guo, Zhao, Fu, Xu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-513c-5p negatively regulates caspase-1 expression in HUVECs. (A) The expression of miR-513c-5p after NC, miR-513c-5p mimics, INC and miR-513c-5p inhibitor transfection was evaluated by qRT-PCR. (B) The expression level of caspase-1 mRNA after NC, miR-513c-5p mimics, INC and miR-513c-5p inhibitor transfection was detected by qRT-PCR. (C,D) Expression of caspase-1 in HUVECs were detected after transfection NC, miR-513c-5p mimics, INC, miR-513c-5p inhibitor by immunofluorescence staining (magnification, ×40). Scale bar = 200 μm. (E,F) Protein expression levels of caspase-1 and GSDMD were examined by Western blot. (G) The expression of IL-1β and IL-18 was detected by ELISA. *p < 0.05, **p < 0.01, and ***p < 0.001, ****p < 0.0001.