. 2022 Apr 19;12(19):11769–11785. doi: 10.1039/d2ra01340a

Histopathological lesion scores in cerebral cortexes and hippocampi following treatment with different fractions of Tamarindus indica (n-hexane, dichloromethane, and ethyl acetate)^a.

Histopathological lesion	+ve control	Treatment with n-hex.	Treatment with DCM	Treatment with EtOAc	Donepezil
Cerebral cortex: necrosis of neurons	3.6 ± 0.01^a	1.6 ± 0.02^c	1.6 ± 0.01^c	0.6 ± 0.01^e	0.6 ± 0.02^e
Neuronophagia	3.4 ± 0.02^a	1.8 ± 0.01^c	0.6 ± 0.02^e	0.6 ± 0.01^e	0.40 ± 0.01^e
Neurofibrillary tangles	3.4 ± 0.01^a	1.00 ± 0.01^d	0.4 ± 0.01^e	0.2 ± 0.01^f	0.2 ± 0.02^f
Gliosis	2.4 ± 0.02^b	0.6 ± 0.01^e	0.4 ± 0.01^e	0	0
Hippocampus: necrosis of pyramidal neurons	3.6 ± 0.04^a	1.6 ± 0.01^c	1.00 ± 0.02^d	0.4 ± 0.01^e	0.2 ± 0.01^f
Neurofibrillary tangles	2.6 ± 0.02^b	1.00 ± 0.04^d	0.4 ± 0.01^e	0	0

n-Hex.: n-hexane; DCM: dichloromethane; EtOAc: ethyl acetate.

Histopathological lesion scores in cerebral cortexes and hippocampi following treatment with different fractions of Tamarindus indica (n-hexane, dichloromethane, and ethyl acetate)a.