Effects of different fractions of Tamarindus indica (n-hexane, dichloromethane, and ethyl acetate) on the levels of Ach and AchE in Alzheimer's disease-induced ratsa.
| Parameter | Control | AlCl3-AD | n-Hexane | Dichloromethane | Ethyl acetate | Donepezil drug |
|---|---|---|---|---|---|---|
| Ach (nmol per g tissue) | 56.50 ± 3.22a | 19.15 ± 0.56b | 42.87 ± 3.30d | 35.00 ± 3.30c | 39.80 ± 3.00d | 39.00 ± 2.21d |
| % Change | −66.10 | −24.10 | −38.05 | −29.55 | −30.97 | |
| % Improvement | 41.98 | 28.05 | 36.54 | 35.13 | ||
| AchE (μmol per g tissue) | 3330.00 ± 300.00d | 9400.00 ± 300.90e | 6430 ± 455.00g | 5200.02 ± 400.02f | 6118.03 ± 360.00g | 5278.03 ± 265.70f |
| % Change | 182.2 | 93.09 | 56.15 | 83.70 | 58.4 | |
| % Improvement | 89.18 | 126.1 | 98.5 | 123.7 |
a
Data are expressed as means ± SD (n = 8). Groups with similar letters are not significantly different, while those with different letters are significantly different at p ≤ 0.05. Ach: acetylcholine; AchE: acetylcholine esterase.