Table 2.

Characteristics of the included studies and diagnostic test performance of NLR to predict mortality in COVID-19

					Hospitalized patients
Study	Year	Country	Language	Patient number	Survivor	Nonsurvivor	Male N (%)	T2DM N (%)	HTN N (%)	COPD N (%)	CHF/CAD N (%)	CKD N (%)	Mean age	Cutoff	AUC	TP	FP	FN	TN	SEN %	SPEC %
Tatum et al.44	2020	AMERICA	ENGLISH	125	102	23	45.6	NA	NA	NA	NA	NA	58.7	10	0.71	12	11	98	4	0.52	0.97
Chen et al.48	2020	CHINA	ENGLISH	681	577	104	53.2	16.7	43	2.2	11.7	4	65	6.7	0.86	87	17	447	130	0.84	0.77
Ok et al.11	2020	TURKEY	ENGLISH	139	126	13	44.4	17.9	23.7	NA	13.6	NA	55.5	5.7	0.85	10	3	113	13	0.83	0.90
Asghar et al.36	2020	PAKISTAN	ENGLISH	100	78	22	69	41	32	3	13	10	52.6	4.2	0.81	19	3	48	30	0.91	0.63
Yan et al.49	2020	CHINA	ENGLISH	1,004	964	40	49.1	10.6	23.4	0.79	7.47	10.15	NA	11.8	0.95	39	1	752	212	0.98	0.78
Basbus et al.38	2020	SPAIN	SPANISH	131	112	9	54.1	6.9	30.5	3.8	5.9	NA	52	3	NA	7	2	69	43	0.78	0.62
Li et al.39	2020	CHINA	CHINESE	93	62	31	59.13	10.75	12.9	6.45	NA	NA	62.1	11.3	0.92	27	4	52	10	0.90	0.84
Song et al.50	2020	CHINA	CHINESE	84	42	42	66.66	NA	NA	NA	NA	NA	66.5	6.1	0.87	32	10	37	5	0.76	0.88
Zhang et al.30	2020	CHINA	CHINESE	154	127	27	52.59	13.63	13.63	5.84	10.38	7.79	69.2	9.4	0.86	20	7	116	11	0.76	0.92
Ramos-penafiel et al.15	2020	MEXICO	ENGLISH	125	81	44	64	21.6	19.2	NA	NA	NA	51	13	0.72	26	18	48	33	0.60	0.60
Xu et al.51	2020	CHINA	ENGLISH	76	44	32	60.53	19.74	35.53	2.63	9.21	6.58	59.1	3.59	0.69	30	2	17	27	0.94	0.39
Ye et al.52	2020	CHINA	ENGLISH	349	297	52	49.6	16.3	29.5	12.6	4.6	4	62	7.13	0.86	41	11	243	54	0.80	0.82
Wang et al.16	2020	CHINA	ENGLISH	131	119	12	42.7	21.4	39.7	NA	NA	NA	64	13.87	0.963	10	2	107	12	0.90	0.90
Zeng et al.53	2021	CHINA	ENGLISH	352	116	15	53.9	NA	NA	NA	NA	NA	NA	7.19	0.828	13	2	74	42	0.93	0.64
Eslamijouybari et al.54	2020	IRAN	ENGLISH	527	429	98	44	NA	NA	NA	NA	NA	NA	6.55	0.703	63	35	268	161	0.65	0.63