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. 2021 Sep 8;148(5):1183–1193. doi: 10.1007/s00432-021-03715-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Immuno-expression of EMT markers within vulvar primary and inguinal lymph node metastases. a–c Primary VSCC with cytoplasmatic expression of vimentin within infiltrative tumor cell nests (a), nuclear staining for cyclin D1 (b), strong (*) and reduced/negative (arrow) membranous staining for e-cadherin (c), indicating epithelial–mesenchymal transition (EMT). (d–f) Tumor deposits within lymph node metastases representing negative staining for vimentin, nuclear positivity for cyclin D1 and diffuse staining for e-cadherin, indicating mesenchymal-epithelial transition (MET) (g, h) Micro-metastatic deposit within an inguinal lymph node (a) representing strong cytoplasmatic staining for vimentin of the majority of tumor cells (*)