Table 7.
Summary of dosimetry data for neurodendocrine tumours treated with [177Lu]Lu-DOTA-TATE, except where explicitly stated otherwise
| First author (year) | # pats | Method for activity quantification | Effective half-life washout (h) | Method for AD calculation | AD per unit administered activity (Gy/GBq) | Ref. |
|---|---|---|---|---|---|---|
| Wehrmann (2007) | 61 | Planar: close to adm., 3 h, 20 h, 44 h, 68 h | Mean ± SD: 75.5 ± 20.9 | Sphere S-value. Volume/mass from CT delineation | Mean ± SD: 9.7 ± 11 | [171] |
|
Wehrmann (2007) [177Lu]Lu-DOTA-NOC |
8 | As above | Mean ± SD: 66.7 ± 16.6 | As above | Mean ± SD: 7.5 ± 8.3 | |
| Garkavij (2010) | 7 |
Hybrid: Planar: 1 h, 24 h, 96 h, 168 h SPECT/CT: 24 h or 96 h |
- | LED, volume/mass from SPECT/CT delineation, mass from CT | Median (range): 6.7 (0.1–20) | [99] |
| Jackson (2013) | 17 | SPECT/CT: 4 h, 24 h, and 72 h | - | Voxel-based, DPK | AD per cycle: 21.4 ± 9.7 Gy (6.6–10.2 GBq per cycle) | [190] |
| Ilan (2015) | 24 | SPECT/CT: 24 h, 96 h, and 168 h | - | Sphere S-value, volume/mass from SPECT/CT delineation | Median (range): 6.8 (1.3–23) (for first cycle) | [72] |
| Kupitz (2017) | 16 | Planar and SPECT/CT: between 4 h and 168 h, all pats 4 h, 24 h, and 72 h | - | Sphere S-values. Volume/mass from CT delineation |
Planar: mean ± SD: 5.3 ± 6.3 Median (range): 3.1 (0.18–25) Hybrid planar-SPECT/CT: mean ± SD: 3.1 ± 2.2 Median (range): 2.7 (0.20–7.9) SPECT/CT: mean ± SD: 2.6 ± 1.5 Median (range): 2.7 (0.16–5.4) |
[191] |
| Roth (2018) | 6 | Planar and SPECT/CT: 1 h, 24 h, 96 h, 168 h |
From SPECT/CT: Mean: 96 h Range: 84 h – 117 h |
LED, volume from SPECT/CT delineation, mass from CT |
Hybrid planar-SPECT/CT: mean: 3.6 SPECT/CT: mean: 3.9 Range: 1.3–7.3 |
[192] |
| Jahn (2019) | 25 | SPECT/CT: 24 h, 96 h, and 168 h | - | Sphere S-values. Volume/mass from SPECT/CT delineation |
Mean: 4.7 Median (range): 3.8 (1.3–15.5) |
[193] |
| Rudisile (2019) | 35 | SPECT/CT: 24 h, 48 h, and 72 h | - | Sphere S-values. Volume/mass from SPECT/CT delineation | Mean ± SD: 2.3 ± 1.83 | [194] |
| Del Prete (2019) | 34 | SPECT/CT: 4 h, 24 h, and 72 h | - | Activity concentration, small VOI in high-uptake region. Sphere S-value | Median (range): 4.4 (0.1–32.0) | [40] |
| Jahn (2021) | 48 | SPECT/CT: 24 h, 96 h, and 168 h | - | Sphere S-values. Volume/mass from SPECT/CT delineation |
Medians for cycles 1, 2, 3, 4, 5, 6 (retrieved from graph) Pancreatic (P): 6.6, 3.9, 2.8, 2.7, 2.6, 1.8 Small-intestine (SI): 4.6, 4.9, 4.1, 3.4, 4.1, 2.8 Range all cycles, grade P and SI: 0.7–23 |
[73] |
| Roth (2021) | 41 | Hybrid: Planar: 1 h, 24 h, 96 h, 168 h SPECT/CT: 24 h |
Grade 1 mean: 103 h, CI: 96–109 h Grade 2 mean: 81 h, CI: 73–90 h |
Voxel-based Monte Carlo, volume from SPECT/CT delineation, mass from CT |
Medians for cycles 1, 2, 3, 4, 5, 6 Grade 1: 4.4, 4.4, 4.1, 3.5, 3.8, 3.2 Grade 2: 3.6, 3.1, 2, 1.6, 1.1, 0.8 Range all cycles, grade 1 and 2: 0.3–10 |
[195] |
AD, absorbed dose; DPK, dose-point kernel; CI, confidence interval