Table 2.

Resource use associated with drug-related grade 3 or 4 adverse events (AEs)

Grade 3 or 4 AE (% of total)	Initial assessment visit	No hospitalisation	Day hospital (< 1 day)	Standard hospitalisation (> 1 day)
Anaemia	100	0	92	8
Anorexia	100	50	50	0
Flushing	100	100	0	0
Asthenia/fatigue	100	100	0	0
Hair colour changes	100	100	0	0
Diarrhoea	100	0	50	50
Dyspnoea	100	0	50	50
Abdominal pain	100	10	90	0
Musculoskeletal pain	100	100	0	0
Peripheral oedema	100	100	0	0
Epistaxis	100	50	50	0
Palmar/plantar erythrodysesthesia	100	100	0	0
Mucosal inflammation	100	50	30	20
Infections	100	100	0	0
Hyperglycaemia	100	0	90	10
Hypertension	100	95	0	5
Leukopenia	100	95	0	5
Lymphopenia	100	100	0	0
Nauseaa	100	100	0	0
Neutropenia	100	95	0	5
Weight loss	100	100	0	0
Pyrexia	100	100	0	0
Pneumonitis	100	0	50	50
Stomatitis	100	50	30	20
Thrombocytopenia	100	0	90	10
Vomitinga	100	50	50	0

^aNausea and vomiting episodes caused by co-administration of amino acids (65% of nausea episodes and 73% of vomiting episodes) were excluded from the calculation, since the related costs were already included in the hospital diagnosis-related group tariff for administration of the drug