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. 2022 Apr 18;79(5):248. doi: 10.1007/s00018-022-04273-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — PI(4,5)P2 accumulates at slit diaphragms, whereas PI(3,4,5)P3 is rather found at the free plasma membrane. (A–D) Garland nephrocytes expressing either UAS::PH(PLCδ)-mCherry for labelling PI(4,5,)P2 or UAS::PH(Akt)-GFP to visualize PI(3,4,5)P3 were dissected from 3rd instar larvae, fixed and stained with the indicated antibodies. A and C are sections through the equatorial region of the nephrocyte; B and D are onviews onto the surface of these nephrocytes. Scale bars are 5 µm and 1 µm in insets