Table 3.
Receiver operating characteristic describing the value of the percentage change in different FDG-PET parameters at the primary tumour site as surrogate marker for a pathological response early upon neoadjuvant ICB. AUC, area under the curve; SUV, standardized uptake value; MTV, metabolic tumour volume; TLG, total lesion glycolysis
| Metabolic parameter | AUC | Threshold | Sensitivity | Specificity | Accuracy |
|---|---|---|---|---|---|
| %ΔSUVmax | 0.760 | − 25% | 1 | 0.63 | 0.86 |
| %ΔSUVmean | 0.901 | − 8.5% | 1 | 0.71 | 0.90 |
| %ΔMTV | 0.978 | − 12.5% | 0.92 | 1 | 0.95 |
| %ΔTLG | 0.978 | − 12.5% | 0.92 | 1 | 0.95 |