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. 2022 Jan 26;42(3):618–633. doi: 10.1007/s10875-021-01201-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — T- and B-lymphocyte subpopulations and immunoglobulin and cytokine levels. a Proportions of T-helper lymphocyte subsets (Th1, Th2 and Th17, Treg naïve, Treg memory). b Proportions of B-lymphocyte subsets (CD19 naïve, IgD+ IgM+ memory, IgM+ only memory, and class-switched). The definitions of the cell types are provided in Supplementary Table S1. c Serum concentrations of IgG, IgA, and IgM. d Plasma concentrations of cytokines. ^#All cytokine concentrations are presented as pg/ml, with the exception of CRP, which is presented in mg/L. IL, Interleukin; TSLP, thymic stromal lymphopoietin; IFN, interferon. Results are shown as individual values for the healthy controls (gray dots), 22q11Normal patients (blue squares), and 22q11Low patients (red triangles). Information on missing data is provided in Supplementary Table S3. Lines denote medians and whiskers indicate the interquartile ranges. P value summary indicated on each graph: *P ≤ .05, **P ≤ .01, ***P ≤ .001.